一、基本信息：
姓 名：王东旭
职 称：副教授、博士生导师
所在部门：大阳城娱乐官网
研究方向：基因表达与动物模型的建立
办公电话：18743089730
电子邮件：wang_dong_xu@jlu.edu.cn
王东旭，博士生导师，大阳城娱乐官网副教授。一直致力于基因表达和动物模型的建立等方面的研究。主持国家青年自然基金1项，吉林省开放课题1项，吉林省优秀青年人才基金1项，中国博士后科学基金2项，吉林省教育厅“十三五”科学研究规划项目1项。近五年来，在国际重要学术期刊发表SCI论文18篇，其中以第一作者发表论文5篇，并列第一作者3篇，通讯作者发表论文10篇。在教学上，讲授本科生《实验动物生产学》，《实验动物繁殖学》，《实验动物学》3门课程。
二、学习与工作经历：
2004–2008，就读于大阳城娱乐官网畜牧兽医学院, 生物技术专业，获得学士学位
2009–2012，就读于大阳城娱乐官网畜牧兽医学院, 生物化学与分子生物学专业，获得硕士学位
2012–2015，就读于大阳城娱乐官网，生物化学与分子生物学专业，获得博士学位
2015–2018，就职于大阳城娱乐官网，实验动物专业，讲师
2018–至今，就职于大阳城娱乐官网，实验动物专业，副教授
2019–至今，就职于大阳城娱乐官网，实验动物专业，博士生导师
承担的科技计划项目：
国家自然青年科学基金项目“猪孤雌发育中印迹基因H19/IGF2表达和甲基化模式的分析”（项目批准号：31601003），2017-2019 主持人
吉林省科技发展计划项目“小鼠肺癌模型中H19表达和甲基化模式的分析”（项目批准号：20170623093-05TC），2017-2019 主持人
中国博士后科学基金第 60 批面上资助项目“VPA/5-AZA调控H19/IGF2表达诱导细胞凋亡的分析”（项目批准号：2016M601384），2017-2019 主持人
中国博士后科学基金第 11 批特别资助项目“维生素C调控人肝癌细胞系中H19表达和甲基化模式分析”（项目批准号：2018T110250），2019-2021 主持人
吉林省科技发展计划项目优秀青年人才基金“小鼠孤雌胚胎发育中XIST表达和表观遗传修饰分析”（项目批准号：20190103071JH），2019-2021 主持人
吉林省教育厅“十三五”科学研究规划项目“小鼠孤雌胚胎发育中H19表达模式的分析”（项目批准号：JJKH20200950KJ），2019-2021 主持人
近五年科研成果：
[1] Jindong Hao, Wang Dongxu*, et al. microRNA-670 modulates Igf2bp1 expression to regulate RNA methylation in parthenogenetic mouse embryonic development [J]. Scientific RepoRtS, 2020. (Online). (Corresponding author)
[2] Xiaowei Zhong, Wang Dongxu*, et al. Galangin promotes cell apoptosis through suppression of H19 expression in hepatocellular carcinoma cells [J]. Cancer Medicine, 2020. (Online). (Corresponding author)
[3] Jindong Hao, Wang Dongxu*, et al. Targeted point mutations of the m 6 A modification in
miR675 using RNA-guided base editing induce cell apoptosis [J]. Bioscience Reports, 2020. (Online). (Corresponding author)
[4] Xiaowei Zhong, Wang Dongxu*, et al. Chrysin induced cell apoptosis and inhibited invasion through regulation of TET1 expression in gastric cancer cells [J]. OncoTargets and Therapy, 2020. (Online). (Corresponding author)
[5] Chen Lin, Wang Dongxu*, et al. Quercetin meditated TET1 expression induces cell apoptosis and suppresses proliferation in melanoma cells [J]. Ciencia e Tecnica Vitivinicola, 2020. (Online). (Corresponding author)
[6] Wei Gao, Wang Dongxu*, et al. Ascorbic acid improves parthenogenetic embryo development through TET proteins in mice [J]. Bioscience Reports, 2018. (Online). (Corresponding author)
[7] Jindong Hao, Wang Dongxu*, et al. The perturbed expression of m6A in parthenogenetic mouse embryos [J]. Genetics and Molecular Biology, 2018. (Online). (Corresponding author)
[8] Xiaowei Zhong, Wang Dongxu*, et al. The expression of TET3 regulated cell proliferation in HepG2 cells [J]. Gene, 2019. (Online). (Corresponding author)
[9] Yuning Song, Wang Dongxu*, Zhanjun Li*, et al. DNA methylation-mediated silencing of FLT1 in parthenogenetic porcine placentas [J]. Placenta, 2017, 58:86-89. (Corresponding author)
[10] Yang Hao, Guodong Wang, Wang Dongxu*, et al. Valproic acid induces decreased expression of H19 in A549 cells [J]. DNA and Cell Biology, 2017;36(6):428-35. (Corresponding author)
[11] Wang Dongxu, Zhanjun Li*. Disruption of NNAT, NAP1L5 and MKRN3 DNA methylation and transcription in rabbit parthenogenetic fetuses [J]. Gene. 2017;626:158-62. (First author)
[12] Wang Dongxu, Zhanjun Li*, DianfengLiu*, et al. DNA methylation modulate H19 and IGF2 expression in porcine female eye [J]. Genet Mol Biol, 2017;40(1):153-9. (First author)
[13] Wang Dong-xu, Zhanjun Li*, Lai Liang-xue*, et al. Faithful Expression of Imprinted Genes in Donor cells of SCNT cloned pigs [J]. FEBS letters. 2015, 589, 2066-72. (First author)
[14] Wang Dong-xu, Zhanjun Li*, Lai Liang-xue*, et al. Disruption of imprinted gene expression and DNA methylation status in porcine parthenogenetic fetuses and placentas [J]. Gene, 2014, 547(2): 351-8. (First author)
[15] Wang Dong-xu, Zhanjun Li*, Lai Liang-xue*, et al. Genomic imprinting analysis of Igf2/H19 in porcine cloned fetuses using parthenogenetic somatic cells as nuclear donors [J]. Biotechnology letters, 2014, 36(10): 1945-52. (First author)
[16] Zhang Xiao-yang, Wang Dong-xu, Han Yang, et al. Altered imprinted gene expression and methylation patterns in mid-gestation aborted cloned porcine fetuses and placentas [J]. Journal of assisted reproduction and genetics, 2014;31(11):1511-7. (Co-first authors)
[17] Lin Chao, Liu Zeng-shan, Wang Dong-xu, et al. Sensitive and reliable micro-plate chemiluminescence enzyme immunoassay for okadaic acid in shellfish [J]. Anal Methods-Uk, 2014, 6(18): 7142-8. (Co-first authors)
[18] Li Xiao-lan, Song Nan, Wang Dong-xu, et al. (2015) Isoform-specific imprinting of the MEST gene in porcine parthenogenetic fetuses. Gene 558: 287-290. (Co-first authors)
